Thesis topics

Dr. István Timári, assistant professor

Application of advanced NMR methods for structure elucidation of biologically active molecules

The biological activity of any molecule is primarily determined by the structure of the given molecule. Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful techniques for investigation of molecular structure in atomic detail. Due to the growing number of regulatory requirements for example in drug development, and consequently the increasing number of measurements required, there is a continuous demand for innovative methods that can provide maximal information in the shortest time possible. We will apply our advanced NMR experiments to boost the structure determination procedure of biologically active compounds, such as carbohydrates, peptides, and metal ion complexes.

 

Analysis of metabolomic samples by multi-dimensional NMR methods

In metabolomics (the systematic study of metabolites), one-dimensional (1D) 1H NMR is still the most frequently applied experiment due to its simplicity and good sensitivity. However, 1D 1H spectra of complex mixtures are often overcrowded, which makes the identification of many metabolites impossible causing a loss of potentially important information. Modern, multi-dimensional NMR methods can overcome many of these issues making the characterization of metabolomics samples more accurate.

  

Updated: 2021.02.03.


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